Amy Schumer has opened up in an honest health update, claiming that Ozempic left her "bedridden".
In a recent wave of candid interviews and social media posts, the 43-year-old comedian revealed a string of deeply personal health revelations, including a battle with Cushing syndrome — a rare disorder caused by prolonged exposure to high levels of cortisol.
“I wouldn’t have known [about Cushing's Syndrome] if the internet hadn’t come for me so hard,” Schumer shared during an appearance on Alex Cooper's Call Her Daddy podcast.
She explained that about “a year ago, the Internet really came for [her]” with cruel comments about her appearance. Initially, she brushed it off. “I was like, ‘Okay, everybody, like, relax,’” she told Cooper.
But the remarks turned serious when doctors chimed in.
“Doctors were chiming in in the comments and they were, like, ‘No, no, something's really up. Your face looks so crazy,’” she said.
Schumer eventually connected the dots.
According to the Mayo Clinic, Cushing syndrome can be triggered by long-term use of steroids — something she unknowingly experienced after receiving steroid injections for scars from her breast reduction and C-section.
“At first, I was like, ‘F*** off,’” she said. “Wait, I have been getting steroid injections for my scars.” She realized: “So it gave me this thing called Cushing syndrome — which I wouldn’t have known if the internet hadn’t come for me so hard.”
Right before filming her new Netflix comedy Kinda Pregnant, which premiered on February 5, Schumer was battling the effects of the condition, including a swollen face, also known as “moon face.”
“I learned I had this condition, and that I had something called moon face, and I’m starring in a movie — and there’s a camera right in my face,” she said.
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Feeling insecure about how she looked on camera, she turned to people around her for reassurance.
“Most people were, like, ‘You look great,’” she shared, “but one friend from high school was, like, ‘Your face is looking, like, a little bit insane.’”
“I was feeling really down on myself before I started filming this movie… I was, like, really having trouble figuring out how I was going to star in a movie while I had this going on,” she admitted.
Fortunately, things began to improve. Schumer explained that Cushing syndrome “just has to work itself out,” and credited director Lorraine Caffery for lifting her spirits. “You know, I think you look f***ing great,” Caffery told her — a comment that helped Schumer bounce back.
“I just needed one person to just amp me up,” she added.
In addition to addressing Cushing syndrome, Schumer also opened up about her rocky relationship with popular weight-loss drugs.
On The Howard Stern Show, she admitted to trying Ozempic — a diabetes medication now widely used for weight management — but said it left her in rough shape.
“I tried Ozempic almost three years ago and I was like, bedridden,” she said. “I was like, vomiting — and then you have no energy. But other people take it and they’re all good.”
Undeterred, Schumer gave similar drugs another shot and recently revealed in an Instagram video that she’s having a better experience this time around with Mounjaro.
“Three years ago, I tried Wegovy,” she shared. “I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever.”
She went on to describe her virtual health referral through the online midlife clinic Midi Health, and revealed she’s also been prescribed estrogen and progesterone to manage perimenopause symptoms.
“So that’s been great and Mounjaro’s been great,” she said.
Though she acknowledged that Mounjaro isn’t fully covered by insurance in the U.S. unless you have diabetes or severe obesity, she joked: “Which most of the internet thinks I have, but I’m having a really good experience with it.
“I wanted to keep it real with you about that.”