Amy Schumer has opened up in an honest health update, claiming that Ozempic left her "bedridden".

In a recent wave of candid interviews and social media posts, the 43-year-old comedian revealed a string of deeply personal health revelations, including a battle with Cushing syndrome — a rare disorder caused by prolonged exposure to high levels of cortisol.

“I wouldn’t have known [about Cushing's Syndrome] if the internet hadn’t come for me so hard,” Schumer shared during an appearance on Alex Cooper's Call Her Daddy podcast.

She explained that about “a year ago, the Internet really came for [her]” with cruel comments about her appearance. Initially, she brushed it off. “I was like, ‘Okay, everybody, like, relax,’” she told Cooper.

But the remarks turned serious when doctors chimed in.

“Doctors were chiming in in the comments and they were, like, ‘No, no, something's really up. Your face looks so crazy,’” she said.

Schumer eventually connected the dots.

According to the Mayo Clinic, Cushing syndrome can be triggered by long-term use of steroids — something she unknowingly experienced after receiving steroid injections for scars from her breast reduction and C-section.

“At first, I was like, ‘F*** off,’” she said. “Wait, I have been getting steroid injections for my scars.” She realized: “So it gave me this thing called Cushing syndrome — which I wouldn’t have known if the internet hadn’t come for me so hard.”

Right before filming her new Netflix comedy Kinda Pregnant, which premiered on February 5, Schumer was battling the effects of the condition, including a swollen face, also known as “moon face.”

“I learned I had this condition, and that I had something called moon face, and I’m starring in a movie — and there’s a camera right in my face,” she said.

Feeling insecure about how she looked on camera, she turned to people around her for reassurance.

“Most people were, like, ‘You look great,’” she shared, “but one friend from high school was, like, ‘Your face is looking, like, a little bit insane.’”

“I was feeling really down on myself before I started filming this movie… I was, like, really having trouble figuring out how I was going to star in a movie while I had this going on,” she admitted.

Fortunately, things began to improve. Schumer explained that Cushing syndrome “just has to work itself out,” and credited director Lorraine Caffery for lifting her spirits. “You know, I think you look f***ing great,” Caffery told her — a comment that helped Schumer bounce back.

“I just needed one person to just amp me up,” she added.

In addition to addressing Cushing syndrome, Schumer also opened up about her rocky relationship with popular weight-loss drugs.

On The Howard Stern Show, she admitted to trying Ozempic — a diabetes medication now widely used for weight management — but said it left her in rough shape.

“I tried Ozempic almost three years ago and I was like, bedridden,” she said. “I was like, vomiting — and then you have no energy. But other people take it and they’re all good.”

Undeterred, Schumer gave similar drugs another shot and recently revealed in an Instagram video that she’s having a better experience this time around with Mounjaro.

“Three years ago, I tried Wegovy,” she shared. “I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever.”

She went on to describe her virtual health referral through the online midlife clinic Midi Health, and revealed she’s also been prescribed estrogen and progesterone to manage perimenopause symptoms.

“So that’s been great and Mounjaro’s been great,” she said.

Though she acknowledged that Mounjaro isn’t fully covered by insurance in the U.S. unless you have diabetes or severe obesity, she joked: “Which most of the internet thinks I have, but I’m having a really good experience with it.

“I wanted to keep it real with you about that.”

Featured image credit: Axelle/Bauer-Griffin / Getty

Amy Schumer is embracing the final weeks of summer by celebrating her recent health transformation. The 45-year-old comedian recently posted a series of bikini photos on Instagram, displaying her physical progress while relaxing by the water.

Wearing a colorful two-piece swimsuit, Schumer smiled for the camera and gave her followers a look into her recent vacation. "I never knew there would be days like this," she captioned the post. "No filter as per ushe."

The social media update quickly gathered positive feedback from both her fans and celebrity friends. Actress Kate Walsh showed her support by commenting, "So beautiful, Amy. Happy and thriving."

The post marks another moment where the actress has chosen to speak openly about her body image and health management.

Finding the right medical balance

Schumer has spent the last two years discussing the realities of her weight-loss experiences, sharing the positive results alongside the difficult side effects.

In March 2025, she uploaded a video addressing her experience with the medication Mounjaro and detailing her past struggles with other injectables.

"I wanted to share and keep it 100 with you, that years ago - and yes, this is completely unsafe to be driving and making a video - years ago, three years ago, I tried Wegovy and I was like puking," Schumer told her followers.

She added that she eventually sought out alternative care options to see what would work for her body. "I couldn't handle it. I don't know if they've changed the formula or whatever… but anyway, I went on this telehealth meeting with MidiHealth, and it was cheap. I wanted to try it myself, cause I wanted to recommend it to my friends who are like nurses and teachers."

In addition to navigating these treatments, she addressed her perimenopause symptoms by starting a new hormone routine. "They put me on estrogen and progesterone because I realized I was in perimenopause and my symptoms of being in perimenopause have disappeared," she noted.

Amy Schumer has been open about her experience with Mounjaro. Credit: Amy Schumer / Instagram

Managing severe side effects and health conditions

Finding a workable routine required significant trial and error for the star. During an appearance on The Howard Stern Show, the comedian explained how her genetic makeup caused severe reactions to certain popular weight-loss drugs.

"I have this gene - GDF15 - which makes you extremely prone to nausea, which is why I was so sick during my pregnancy. So, I tried Ozempic almost three years ago and I was like bedridden, I was vomiting, and then you have no energy but other people take it, and they're all good," she stated.

Although the physical changes happened rapidly, the toll on her daily life was too high. "I lost 30 pounds so quick," said Schumer, who is mom to four-year-old son Gene, whom she shares with ex-husband, Chris Fischer. "I looked great, and I couldn't lift my head off the pillow, so what's the point?"

Beyond her weight-loss experiences, Schumer has routinely used her platform to bring attention to various women's health issues.

In February 2024, she shared her Cushing syndrome diagnosis after observers noted changes in her face, later calling the medical discovery a blessing because it helped pinpoint the root cause of her symptoms.

She has also spoken openly about her struggles with endometriosis and her 2021 hysterectomy, consistently using her public profile to normalize discussions about medical challenges.

Featured image credit: Amy Schumer / Instagram

Amy Schumer has candidly opened up about the reason for her weight loss after cruel trolls targeted her appearance.

The comedian and actress, 44, has kept her fans updated throughout her health journey, having lost 50lb.

However, she revealed that the reason for her weight loss was not purely cosmetic - it was to help her "survive" a disease she discovered she had after getting comments about her "puffy" face.

Schumer shared a video taken by her six-year-old son, Gene, which she'd overlaid with information about her condition.

She wrote: "Bedroom tour by Gene. I never ever wear jewelry. I don't get Botox or filler. I didn't lose 30lbs I lost 50.

"Not to look hot which does feel fun and temporary. I did it to survive.

"I had a disease that makes your face extremely puffy that can kill you, but the internet caught it, and the disease has cleared."

Schumer appeared to be referring to her Cushing syndrome diagnosis, which is a condition caused by the body having too much cortisol, the primary stress hormone, per the Mayo Clinic.

The condition can cause weight gain in the trunk as well as the face, high blood pressure, and increased stretch marks, as well as skin that bruises more easily.

She added: "Sorry for whatever feeling it's giving you that I lost that weight. I've had plastic surgery over the years and I use Mounjaro.

"Sorry to anyone that lets down. I am pain free and can [play] tag with my son."

She also addressed being in perimenopause as well as the rumors about her marriage to her husband, Chris Fischer, who was diagnosed with autism, adding: "Whatever ends up happening with Chris has nothing to do with weight loss or autism. Fingers crossed we can make it through, he's the best."

A source told People before the couple ultimately ended their relationship: "They’re privately working through normal issues that couples in long-term marriages have. They are both committed to the relationship."

Schumer had spoken out about being diagnosed with Cushing's Syndrome - which some have linked to steroid injections - saying on the Call Her Daddy podcast: "So I got these was getting these steroid injections and so it gave me this thing called Cushing syndrome — which I wouldn't have known if the internet hadn't come for me so hard."

Featured image credit: Raymond Hall/GC Images/Getty Images

Amy Schumer told fans that she underwent an operation that has harmed her libido.

The actress has never been shy in updating fans with her health journey, having opened up about her weight loss journey and use of Ozempic in the past.

Schumer, 44, has also spoken extensively about her sexual history over the years, which includes steamy scenes with John Cena for 2015 film Trainwreck, or some real-life habits that she has between the sheets.

But it seems like her recent health condition has caused her sex life to take a hit, just months after confirming that she and her husband of seven years, Chris Fischer, were getting a divorce.

Schumer spoke at a recent event, revealing that she had undergone a colonoscopy, but this didn't go to plan, and it has left its mark on her.

Amy Schumer has hidden close to nothing about her personal life over the years. Credit: Instagram/@amyschumer

"Botched" colonoscopy left Schumer worse for wear

When speaking to Amanda Hirsch during an event for Hirsch’s Not Skinny But Not Fat podcast, she admitted: “I feel happier than I’ve ever been before.”

The host then asked if it had anything "to do with being really hot," and while Schumer was appreciative of the comment, she revealed that this was wide of the mark.

She explained: “I actually had kind of a botched colonoscopy, so I’m not feeling very sexual.”

While the mom didn't open up about the procedure any further, she did joke: “See, that’s another thing you’re not going to have to worry about for 15 years.”

Schumer's health struggles

Last year, Schumer wrote about a recent 50-pound (22.7kg) weight loss, which occurred as a result of her Cushing Syndrome diagnosis.

This condition can result in a round face, weight gain, high blood pressure, and bone loss.

She explained in an Instagram post: “I didn’t lose 30lbs, I lost 50,

“Not to look hot, which does feel fun and temporary. I did it to survive. I had a disease that makes your face extremely puffy and can kill you but the internet caught it and that disease has cleared.

“Sorry for whatever feeling it’s giving you that I lost that weight,” she added, admitting that she had used weight loss drugs and undergone plastic surgery as well.

Schumer stated: “I’ve had plastic surgery over the years, and I use Mounjaro.

"Sorry to anyone [who] feels let down. I’m pain-free. I can [play] tag with my son.”

Amy Schumer is the definition of an open book in the celebrity world. Credit: Dia Dipasupil/Getty

Schumer's sex confession

Speaking on the Call Her Daddy podcast last year, Schumer said: "I’ve never said this anywhere, but when I was at sort of, kind of my peak, touring arenas, whatever, and I’ll say it... were they a professional athlete? Sure.

"Did I text them late at night and they came over, went down on me and then I said, ‘I’m so tired, I’m so sorry,’ and they left? Yes.

“And you know who you are."

Schumer has since revealed the athlete was a baseball player, but understandably has not revealed their identity, except that he was 'pretty cool' about the situation she claims 'not [to be] proud of”'

The comedian added: "You wanna be a giving lover, whatever, whatever. But at this moment it was like, you know, some people will blow a guy and that’s the end of the night.

"So I kind of did it my way, to quote Frank Sinatra."

Although Schumer did not let on when the sexual encounter happened, it must have been over ten years ago, as it inspired a well-loved scene in her 2015 movie Trainwreck.

She confessed: “He went down on me and then I yawned and was like [I’m tired], that’s a moment in Trainwreck that’s from real life.

"That's happened probably three times in my life when I was in my heyday, one of them was furious and one of them was totally fine with it.

"And the baseball player was kinda cool about it."

Featured image credit: Amy Schumer/Instagram.

Amy Schumer has responded after online users used the same one word in reaction to her dramatic body transformation post.

The 44-year-old comedian is receiving an outpouring of strong reactions from her fans and celebrity friends after unveiling a newly toned figure on an Instagram post on Sunday (October 5).

The picture, which was captioned "My lovies," shows Schumer donning a sleek black Miu Miu minidress while standing next to friends Jillian Bell and Alex Saks.

Reactions From Peers And Followers

Fans and celebs alike kept repeating the same one word in the comments: "legs".

The post quickly garnered attention from the comic's famous peers. Comedian Kathy Griffin jokingly wrote: “I’m so pissed about your legs, I can barely talk to you,” while writer-director Lee Daniels, known for Precious and Empire, commented: “Skinnnnnnnny mommmmma.”

Amy Sedaris chimed in: "You look incredible. Look at those pins!!!" while fashion designers Margaret Josephs added: "Ok legs for days!!" alongside the fire emoji.

By Monday, Schumer took to her Instagram to thank her followers for their compliments: sharing, “Loving the love. My legs thank you!”

Schumer's Weight Loss and Health Struggles

While the I Feel Pretty actress didn't go into detail about her weight loss in the recent post, she had previously addressed her health journey earlier this year.

Schumer confirmed that she had been taking Mounjaro, a medication in the same class as Ozempic, which has been used off-label for weight loss, HuffPost reported.

She has also been open about her previous experiences with weight management medications, including her time using Wegovy, another GLP-1 medication, which she ultimately stopped as it left her "bedridden".

“I tried Ozempic almost three years ago, and I was like, bedridden,” she said on The Howard Stern Show. “I was like, vomiting - and then you have no energy. But other people take it and they’re all good.”

In past interviews, the Trainwreck star has been transparent about her struggles with body image. In 2022, she revealed that she underwent liposuction after giving birth to her son, Gene, via C-section three years earlier.

Additionally, Schumer has faced scrutiny for her appearance, including accusations of plastic surgery when her face appeared puffier in 2022. She later clarified that the change in her appearance was due to endometriosis and a diagnosis of Cushing's syndrome, a condition caused by high cortisol levels, which can result in weight gain, fatigue, and other symptoms.

Schumer's Candidness About Weight Loss Medications

Throughout her health journey, Schumer has spoken out about the importance of transparency in discussions about weight loss.

After revealing her liposuction procedure, the comedian emphasized the importance of being honest about such choices. "I just wanted to say that, because if anybody sees me in pictures or anything and they're like, she looks thinner, and whatever: it's because I had a surgery," she said on Dear Chelsea in 2022. "It's too hard, and I just want to be real about it."

Schumer continued her push for transparency in 2023, criticizing the culture of dishonesty surrounding weight loss. “Everyone has been lying saying, ‘Oh smaller portions.’ Like shut the f*** up. You are on Ozempic or one of those things, or you got work done. Just stop,” she said on Watch What Happens Live in 2023. “Be real with the people. When I got lipo, I said I got lipo.”

Featured image credit: Dia Dipasupil / Getty