Innovation3 min(s) read
Published 16:09 23 Jun 2026 GMT
One major weight loss mistake many Ozempic users are making, according to study
A recent study has shown that many people taking GLP-1 medications to lose weight are not taking them correctly, and it could be detrimental to achieving results.
According to the new research by the Endocrine Society, people with obesity who lost weight using drugs such as Ozempic or Wegovy “significantly reduced” their physical activity.
Failing to exercise while using the GLP-1s could be harmful, as drugs such as semaglutide, liraglutide, dulaglutide, and tirzepatide reduce both fat and lean muscle mass.
Study lead Sajana Maharjan, MD, of HSHS St. John’s Hospital in Springfield, Illinois, said keeping active and building muscle is “essential for preserving strength and long-term health.”
The study found that men were less active than women while losing weight
By comparing activity in study participants before and after beginning treatment, researchers found that the average number of steps decreased from 5,047 to 4,487 per day, while moderate physical activity fell from 28 to 22 minutes per day.
Although the cohort was mostly female, with an average age of 52.7 years, the largest declines were observed in men and in those with joint or muscle pain
The data was recorded from 753 people with obesity who began taking a GLP-1 medication during the trial.
Despite the common belief that losing weight, medically aided or not, would encourage people to increase their physical activity, the study seems to have proved the opposite.
Maharjan addressed the importance of people taking GLP-1s to continue or increase the amount they exercise, saying: “The findings in our study reinforce that exercise cannot be optional for people taking these medications.
“People need targeted interventions that encourage physical activity alongside medication for obesity.”
Why is exercising important if the weight is coming off without it?
Supporting the findings of the study, a New York-based hormone and weight-loss specialist, Dr. Peter Balazs, MD, told Fox News that the findings did not come as much of a surprise to him because weight loss rarely results in a greater motivation to exercise.
He said: “In fact, being in a calorie deficit can cause the body to conserve energy, resulting in a lower metabolic rate.
“Additionally, side effects of weight-loss medications, such as nausea, fatigue or gastrointestinal discomfort, may further reduce a person’s ability or desire to be physically active.”
Balazs also warned that “exercise plays a critical role during weight loss.
“Without adequate physical activity, a significant portion of weight loss may come from muscle rather than fat.”













